Publications

Preprints

(Click titles for link to publishers website; ⊥ = equal contribution; * = corresponding authors)

1. Total Synthesis of the Brevicidine and Laterocidine Family of Lipopeptide Antibiotics

K. A. Ayed⊥, R. D. Ballantine⊥, Z. Zhong, Y-X. Li, S. A. Cochrane* and N. I. Martin*

ChemRxiv 2021, DOI: https://doi.org/10.26434/chemrxiv.13660949.v1.

 

Publications

(Click titles for link to publishers website; ⊥ = equal contribution; * = corresponding authors)

24. Binding Studies Reveal Phospholipid Specificity and its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

I. Kotsogianni, T. M. Wood, F. M. Alexander, S. A. Cochrane and N. I. Martin*

ACS Infectious Diseases2021, accepted.

 

 

23. The Tridecaptins: Non-Ribosomal Peptides That Selectively Target Gram-Negative Bacteria

S. J. Bann, R. D. Ballantine and S. A. Cochrane*

RSC Med. Chem. 202112, 538.

 

22. Undecaprenol Kinase: Function, Mechanism and Substrate Specificity of a Potential Antibiotic Target

B. R. Baker, C. M. Ives, A. Bray, M. Caffrey* and S. A. Cochrane*

Eur. J. Med. Chem. 2021, 210, 113062.

 

21. From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets

R. V. K. Cochrane, F. M. Alexander, C. Boland, S. K. Fetics, M. Caffrey and S. A. Cochrane*

Chem. Commun., 2020, 56, 8603.

 

20. Breaking Down the Cell Wall: Strategies for Antibiotic Discovery Targeting Bacterial Transpeptidases

S. A. Cochrane and C. T. Lohans*

Eur. J. Med. Chem. 2020, 194, 113062.

 

19. Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars

C. Calabrese, I. Uriarte, A. Insausti, M. Vallejo-López, F. J. Basterretxea, S. A. Cochrane, B. G. Davis*, F. Corzana*, and E. J. Cocinero*

ACS Cent. Sci. 2020, 6, 293.

 

18. A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases

S. J. Bann, R. D. Ballantine, Y-X. Li, P-Y. Qian and S. A. Cochrane*

J. Med. Chem. 2019, 62, 10466.

 

17. Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell Wall Precursor Lipid II

S. Chiorean, I. Antwi, D. W. Carney, I. Kotsogianni, A. M. Giltrap, F. M. Alexander, S. A. Cochrane, R. J. Payne, N. I. Martin, A. Henninot and J. C. Vederas*

ChemBioChem 2019, 21, 781.

 

16. Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

R. D. Ballantine, C. E. McCallion, E. Nassour, S. Tokajian and S. A. Cochrane*

Med. Chem. Commun. 2019, 10, 484.

 

15. Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1

R. D. Ballantine,  Y-X. Li,  P-Y. Qian  and S. A. Cochrane*

Chem. Commun. 2018, 54, 10634.

 

 

14. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147

A. Bakhtiary, S. A. Cochrane, P. Mercier, R. T. McKay, M. Miskolzie, C. Sit and J. C. Vederas*

J. Am. Chem. Soc. 2017139, 17803.

 

Postdoctoral and PhD work:

13. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Y. Y. Dong, H. Wang, A. C. W. Pike, S. A. Cochrane, S. Hamedzadeh, F. J. Wyszyński, S. R. Bushell, S. F. Royer, D. A. Widdick, A. Sajid, H. I. Boshoff, Y. Park, R. Lucas, W-M. Liu, S. S. Lee, T. Machida, L. Minall, S. Mehmood, K. Belaya, W-W. Liu, A. Chu, L. Shrestha, S. M.M. Mukhopadhyay, C. Strain-Damerell, R. Chalk, N. A. Burgess-Brown, M. J. Bibb, C. E. Barry 3rd, C. V. Robinson, D. Beeson, B. G. Davis* and E. P. Carpenter*.

Cell 2018, 175, 1045.

 

 

 

12. The Antimicrobial Lipopeptide Tridecaptin A1 Selectively Binds to Gram-Negative Lipid II

S. A. Cochrane, B. Findlay, A. Bakhtiary, J. Z. Acedo, W. M. Rodriguez-Lopez, P. Mercier and J. C. Vederas*

Proc. Natl. Acad. Sci. USA 2016, 113, 11561

Publications figure showing the NMR solution structure of the tridecaptin A1:lipid II complex

Publications figure showing the NMR solution-structure of the tridecaptin A1:lipid II complex 

Recommended in F1000 Prime

 

11. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates

S. A. Cochrane and J. C. Vederas*

Med. Res. Rev. 201636, 4

 

10. Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity Against Gram-Negative Bacteria

S. A. Cochrane, X. Li, S. He, M. Yu, M. Wu and J. C. Vederas*

J. Med. Chem. 201558, 9779

Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity Against Gram-Negative Bacteria Table of Contents Entry

9. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1

S. A. Cochrane, R. R. Surgenor, K. M. W. Khey and J. C. Vederas*

Org. Lett. 201517, 5428

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1 Table of Contents Entry

8. Studies on Tridecaptin B1, a New Tridecaptin Analogue with Activity Against Multidrug Resistant Gram-Negative Bacteria

S. A. Cochrane, C. T. Lohans, M. J. Van Belkum, M. Bels, and J. C. Vederas*

Org. Biomol. Chem. 201513, 6073

Studies on Tridecaptin B1, a New Tridecaptin Analogue with Activity Against Multidrug Resistant Gram-Negative Bacteria Table of Contents Entry

2015 OBC Hot Article

 

7. Molecular Cloning and Characterization of Drimenol Synthase from Valerian (Valeriana officinalis)

M. Kwon, S. A. Cochrane, J. C. Vederas, and D. K. Ro*

FEBS Lett. 2014588, 4597

Publications figure of the proposed drimenol synthase mechanism

Publications figure showing proposed mechanism of drimenol synthase

 

6. Unacylated Tridecaptin A1 Acts as an Effective Sensitizer of Gram-Negative Bacteria to Other Antibiotics

S. A. Cochrane and J. C. Vederas*

Int. J. Antimicrob. Agents 2014, 44, 493

 

5. Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane

S. A. Cochrane, B. Findlay, J. C. Vederas and E. S. Ratemi*

ChemBioChem 201415, 1295

Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane Table of Contents Entry

 

4. Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A1

S. A. Cochrane, C. T. Lohans, J. R. Brandelli, G. Mulvey, G. D. Armstrong and J. C. Vederas*

J. Med. Chem. 2014,  57, 1127

Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A1 Table of Contents Entry

3. Biochemical, Structural and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni

C. T. Lohans, M. J. van Belkum, S. A. Cochrane, Z. Huang, C. S. Sit, L. M. McMullen and J. C. Vederas*

ChemBioChem 2014, 15, 243

Publications figure showing putative tridecaptin A1 non-ribosomal peptide synthetase gene cluster

Publications figure showing putative tridecaptin A1 non-ribosomal peptide synthetase gene cluster

 

2. Investigation of the Ring-Closing Metathesis of Peptides in Water

S. A. Cochrane, Z. Huang and J. C. Vederas*

Org. Biomol. Chem. 2013, 11, 630

Investigation of the Ring-Closing Metathesis of Peptides in Water Table of Contents EntryOBC Hot Article

 

1. Solid Supported Chemical Synthesis of Both Components of the Lantibiotic Lacticin 3147

W. Liu, A. S. H. Chan, H. Liu, S. A. Cochrane and J. C. Vederas*

J. Am. Chem. Soc. 2011133, 14216

Solid Supported Chemical Synthesis of Both Components of the Lantibiotic Lacticin 3147 Table of Contents Entry