Publications
Publications
(Click titles for link to publishers website; ⊥ = equal contribution; * = corresponding authors)
36. Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress
A. M. Giltrap, N. Morris, Y. Y. Dong, S. A. Cochrane, T. Krulle, S. Hoekman, M. Semmelroth, C. Wollnik, E. P. Carpenter, Y. Rudhard, J. Hollick, A. Parkes, B. G. Davis*
ACS Cent. Sci. 2024, submitted
35. A Novel Approach for the Synthesis of the Cyclic Lipopeptide Globomycin
S. J. Bann, S. A. Cochrane*
RSC Med. Chem. 2024, submitted
P. J. Alexander, L. B. Oyama, H. Olleik, F. Godoy Santos, S. O’Brien, A. Cookson, S. A. Cochrane, B. F. Gilmore, M. Maresca, S. A. Huws*
NPJ Biofilms Microbiomes 2024, accepted
N. P. Buijs, H. C. Vlaming, I. Kotsogianni, M. Arts, J. J. Willemse, Y. Duan, F. M. Alexander, S. A. Cochrane, Tanja Schneider, Nathaniel I. Martin*
Proc. Natl. Acad. Sci. USA 2024, 121, e2315310121
N. V. Machushynets, K. Al Ayed, B. Terlouw, C. Du, N. Buijs, J. Willemse, S. S. Elsayed, J. Schill, V. Trebosc, M. Pieren, F. M. Alexander, S. A. Cochrane, M. R. Liles, M. H. Medema, N. I. Martin, G. P. van Wezel
ACS Chem. Biol. 2024, 19, 1106-1115
31. De novo design of cyclic peptide inhibitors of a bacterial membrane lipoprotein peptidases
T. W. Craven⊥, M. D. Nolan⊥, J. Bailey⊥,S. Olatunji, S. J. Bann, K. Bowen, N. Ostrovitsa, T. M. Da Costa, R. D. Ballantine, D. Weichert, P. M. Levine, L. J. Stewart, G. Bhardwaj, J. A. Geoghegan,* S. A. Cochrane,* E. M. Scanlan,* M. Caffrey,* D. Baker*
ACS Chem. Biol. 2024, 19, 1125-1130
30. Plectasin kills bacteria by a Ca2+-sensitive supramolecular mechanism
S. Jekhmane, M. G. N. Derks, S. Maity, C. J. Slingerland, K. H. M. E. Tehrani, J. Medeiros-Silva, V. J. Charitou, D. Ammerlaan, C. Fetz, N. A. Consoli, R. V. K. Cochrane, E. J. Matheson, M. van der Weijde, B. O. W. Elenbaas, F. Lavore, R. Cox, J. H. F. F. Lorent, M. Baldus, M. Kunzler, M. Lelli, S. A. Cochrane, N. I. Martin, W. H. Roos, E. Breukink*, M. Weingarth*
Nat. Microbiol. 2024, 9, 1778–1791
M. Karak, C. R. Cloonan, B. R. Baker, R. V. K. Cochrane, S. A. Cochrane*
Beilstein J. Org. Chem. 2024, 20, 220-227
N. P. Buijse⊥, E. J. Matheson⊥, S. A. Cochrane* and N. I. Martin*
Chem. Commun. 2023, 59, 7685-7703.
R. D. Ballantine⊥, K. Al Ayed⊥, S. J. Bann, M. Hoekstra, N. I. Martin* and S. A. Cochrane*
J. Med. Chem. 2023, 66, 6002-6009.
R. D. Ballantine⊥, K. Al Ayed⊥, S. J. Bann, M. Hoekstra, N. I. Martin* and S. A. Cochrane*
RSC Med. Chem. 2022, 13, 1640-1643.
K. Al Ayed⊥, R. D. Ballantine⊥, M. Hoekstra, S. J. Bann, C. M. J. Wesseling, A. T. Bakker, Z. Zhong, Y-X Li, N. C. Brüchle, M. van der Stelt, S. A. Cochrane* and N. I. Martin*
Chem. Sci. 2022, 13, 3563.
I. Kotsogianni, T. M. Wood, F. M. Alexander, S. A. Cochrane and N. I. Martin*
ACS Infectious Diseases, 2021, 7, 2612.
23. The Tridecaptins: Non-Ribosomal Peptides That Selectively Target Gram-Negative Bacteria
S. J. Bann, R. D. Ballantine and S. A. Cochrane*
RSC Med. Chem. 2021, 12, 538.
B. R. Baker, C. M. Ives, A. Bray, M. Caffrey* and S. A. Cochrane*
Eur. J. Med. Chem. 2021, 210, 113062.
R. V. K. Cochrane, F. M. Alexander, C. Boland, S. K. Fetics, M. Caffrey and S. A. Cochrane*
Chem. Commun., 2020, 56, 8603.
S. A. Cochrane and C. T. Lohans*
Eur. J. Med. Chem. 2020, 194, 113062.
19. Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars
C. Calabrese, I. Uriarte, A. Insausti, M. Vallejo-López, F. J. Basterretxea, S. A. Cochrane, B. G. Davis*, F. Corzana*, and E. J. Cocinero*
ACS Cent. Sci. 2020, 6, 293.
S. J. Bann, R. D. Ballantine, Y-X. Li, P-Y. Qian and S. A. Cochrane*
J. Med. Chem. 2019, 62, 10466.
S. Chiorean, I. Antwi, D. W. Carney, I. Kotsogianni, A. M. Giltrap, F. M. Alexander, S. A. Cochrane, R. J. Payne, N. I. Martin, A. Henninot and J. C. Vederas*
ChemBioChem 2019, 21, 781.
R. D. Ballantine, C. E. McCallion, E. Nassour, S. Tokajian and S. A. Cochrane*
Med. Chem. Commun. 2019, 10, 484.
15. Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1
R. D. Ballantine, Y-X. Li, P-Y. Qian and S. A. Cochrane*
Chem. Commun. 2018, 54, 10634.
14. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147
A. Bakhtiary, S. A. Cochrane, P. Mercier, R. T. McKay, M. Miskolzie, C. Sit and J. C. Vederas*
J. Am. Chem. Soc. 2017, 139, 17803.
13. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design
Y. Y. Dong, H. Wang, A. C. W. Pike, S. A. Cochrane, S. Hamedzadeh, F. J. Wyszyński, S. R. Bushell, S. F. Royer, D. A. Widdick, A. Sajid, H. I. Boshoff, Y. Park, R. Lucas, W-M. Liu, S. S. Lee, T. Machida, L. Minall, S. Mehmood, K. Belaya, W-W. Liu, A. Chu, L. Shrestha, S. M.M. Mukhopadhyay, C. Strain-Damerell, R. Chalk, N. A. Burgess-Brown, M. J. Bibb, C. E. Barry 3rd, C. V. Robinson, D. Beeson, B. G. Davis* and E. P. Carpenter*.
Cell 2018, 175, 1045.
12. The Antimicrobial Lipopeptide Tridecaptin A1 Selectively Binds to Gram-Negative Lipid II
S. A. Cochrane, B. Findlay, A. Bakhtiary, J. Z. Acedo, W. M. Rodriguez-Lopez, P. Mercier and J. C. Vederas*
Proc. Natl. Acad. Sci. USA 2016, 113, 11561
Publications figure showing the NMR solution-structure of the tridecaptin A1:lipid II complex
11. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates
S. A. Cochrane and J. C. Vederas*
Med. Res. Rev. 2016, 36, 4
S. A. Cochrane, X. Li, S. He, M. Yu, M. Wu and J. C. Vederas*
J. Med. Chem. 2015, 58, 9779
9. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1
S. A. Cochrane, R. R. Surgenor, K. M. W. Khey and J. C. Vederas*
Org. Lett. 2015, 17, 5428
S. A. Cochrane, C. T. Lohans, M. J. Van Belkum, M. Bels, and J. C. Vederas*
Org. Biomol. Chem. 2015, 13, 6073
7. Molecular Cloning and Characterization of Drimenol Synthase from Valerian (Valeriana officinalis)
M. Kwon, S. A. Cochrane, J. C. Vederas, and D. K. Ro*
FEBS Lett. 2014, 588, 4597
Publications figure showing proposed mechanism of drimenol synthase
S. A. Cochrane and J. C. Vederas*
Int. J. Antimicrob. Agents 2014, 44, 493
5. Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane
S. A. Cochrane, B. Findlay, J. C. Vederas and E. S. Ratemi*
ChemBioChem 2014, 15, 1295
S. A. Cochrane, C. T. Lohans, J. R. Brandelli, G. Mulvey, G. D. Armstrong and J. C. Vederas*
J. Med. Chem. 2014, 57, 1127
C. T. Lohans, M. J. van Belkum, S. A. Cochrane, Z. Huang, C. S. Sit, L. M. McMullen and J. C. Vederas*
ChemBioChem 2014, 15, 243
Publications figure showing putative tridecaptin A1 non-ribosomal peptide synthetase gene cluster
2. Investigation of the Ring-Closing Metathesis of Peptides in Water
S. A. Cochrane, Z. Huang and J. C. Vederas*
Org. Biomol. Chem. 2013, 11, 630
1. Solid Supported Chemical Synthesis of Both Components of the Lantibiotic Lacticin 3147
W. Liu, A. S. H. Chan, H. Liu, S. A. Cochrane and J. C. Vederas*
J. Am. Chem. Soc. 2011, 133, 14216